ON THE ECONOMIC LINK BETWEEN ASSET PRICES AND REAL ACTIVITY

This paper presents a model linking two financial markets (stocks and bonds) with the real business cycle, in the framework of the Consumption Capital Asset Pricing Model with Generalized Isoelastic Preferences. Besides interest rate term spread, the model includes a new variable to forecast economic activity: stock market term spread, which constitutes the slope of expected stock market returns. The empirical evidence documented in this paper suggests systematic relationships between the state of the business cycle and the shapes of two yield curves (interest rates and expected stock returns). Results are robust to changes in measures of economic growth, stock prices, interest rates and expectation-generating mechanisms.

Analysis of tourism competitiveness and the key influencers

The aim of this research is measure and analyse the tourism competitiveness, which has become one of the great challenges of tourism researchers in recent years. We analyze the relationship between tourism competitiveness and major tourist magnitudes, relations with most tourist destinations, and some pillars that measure competitiveness such as sustainability. A methodology for calculating an indicator of tourism competitiveness based on a double reference point is proposed, taking into account a level of aspiration and reserve level for each pillar of competitiveness. They are considered different degrees of offset between the pillars so that a series of synthetic indices are calculated. Later the rankings obtained for each country are analyzed and conducted a series of analyses. This tool provides managers with a useful and accurate tool, an interactive flexible and easy to use multi-criteria decision on their part. Allows simulation of situations, monitoring and control of various indicators. Later statistical tools for analyzing and comparing tourism competitiveness and other quantities are used.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Principles for Consciousness in Integrated Cognitive Control

In this article we will argue that given certain conditions for the evolution of bi- \ud ological controllers, these will necessarily evolve in the direction of incorporating \ud consciousness capabilities. We will also see what are the necessary mechanics for \ud the provision of these capabilities and extrapolate this vision to the world of artifi- \ud cial systems postulating seven design principles for conscious systems. This article \ud was published in the journal Neural Networks special issue on brain and conscious- \ud ness

Applications of Polyanionic Carbosilane Dendrimers against HIV-1 and HCMV

Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de Lectura: 24-01-2022Viral outbreaks are one of the main foci nowadays due to the actual Sars-Cov2 pandemic. Therefore, new therapies and treatments are needed to fight, not only the new viral challenges, but also viruses that in several countries have caused a non-stop pandemic since several years ago, as Human Immunodeficiency Virus (VIH) or Human Cytomegalovirus (HCMV). The high cost of present treatments and the lack of routinely tests in these countries urge the necessity to develop new molecules or strategies against these viruses. Foremost, in immunosuppressed individuals, as HIV patients, HCMV infection can lead to dissemination and life-threatening end-organ diseases. The new treatments should be low-cost and capable of avoiding the emerging problem of resistant virus. Nanotechnology is rising as a promising alternative in response to the need of efficient, immediate and cost-effective therapies. Dendrimers are a group of nanoparticles that have shown promising results against viral infectious diseases. In this work we demonstrated three different applications of Polyanionic Carbosilane Dendrimers. First, we showed the reactivation activity of G3-S16 in a monocytic derived cell line, and the promising results in the combination with the actual Latency Reversal Agents for the “Shock and Kill” approach. Second, we evaluated the ability of G2-S16 dendrimer to inhibit HIV cell to cell transmission in Monocyte Derived Macrophages (MDMs). We co cultured, treated, and infected MDMs with healthy T lymphocytes to measure cell to cell transmission, our results showed that G2-S16 is capable of inhibit HIV infectivity inside MDMs, thus reducing or eliminating reservoir or sanctuaries formation. Third, we demonstrated the potent inhibition activity of G2-S16 and G2-S24P against HCMV infection in human lung fibroblast. We studied the mechanism of action of these dendrimers, showing that in contrast with other viruses, G2-S16 and G2-S24P do not inhibit HCMV attachment in MRC-5. Moreover, we evaluated the combination of both dendrimers with the actual treatment, ganciclovir, the results showed an increased potency and time effect against HCMV infectionThis thesis is based upon work from COST Action CA 17140 “Cancer Nanomedicine from the Bench to the Bedside” supported by COST (European Cooperation in Science and Technology). The Spanish HIV BioBank is supported by Instituto de Salud Carlos III, Spanish Healt Ministry (Grant nº RD06/0006/0035, RD12/0017/0037 and RD16/0025/0019) as part of the Plan Nacional R + D + I and cofinanced by ISCIII- Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER)”. The RIS Cohort (CoRIS) is funded by the Instituto de Salud Carlos III through the Red Temática de Investigación Cooperativa en SIDA (RIS C03/173, RD12/0017/0018 and RD16/0002/0006) as part of the Plan Nacional R + D + I and cofinanced by ISCIII-Subdirección General de Evaluacion y el Fondo Europeo de Desarrollo Regional (FEDER) 2018-202